Modified Fasting 101: The Ultimate Beginner’s Guide
If you’re like most people, the idea of going without food for a day — or even longer — doesn’t sound very sexy.
But unless you’ve been living under a rock, you’ve probably heard about the incredible health benefits of fasting.
Maybe you know that in 2016, the Nobel Prize for Medicine was awarded for new research that revealed exactly why fasting is so powerful1 (More on that below!).
So what if I told you that you that it was possible to get the benefits of fasting without going hungry (or getting hangry)?
Intrigued? You should be! Let’s talk modified fasting.
In this article:
- What Is Modified Fasting?
- How Does Modified Fasting Work?
- Frequently Asked Questions About Modified Fasting
- The Unique Benefits of Modified Fasting
- Advantages of a Modified Fast vs. Longer Fasts
- Tips for a Successful Modified Fast
- Conclusions about Modified Fasting
What Is Modified Fasting?
Modified fasting is a type of intermittent fasting2 that gives you a budget of 600-800 calories a day, for three or more days, and restricts eating to an 8- to 12-hour window. Of course, those calories can’t come from DingDongs — but rather a power-packed, plant-based meal plan that includes the right balance of carbohydrates, protein, fat, and micronutrients. (More on that in a minute, too.)
In the recent past, a lot of experts argued that fasting had to be strict (no calorie intake whatsoever) to be most effective. However, a tidal wave of human and animal clinical studies, as well as new breakthrough research from Valter Long, PhD, shows that modified fasting yields the same health benefits of a zero-calorie water fast,3 including weight loss, mental clarity, reduced inflammation, and cellular renewal and repair.
How Does Modified Fasting Work?
In 2016, Japanese biologist Dr. Yoshinori Ohsumi won a Nobel prize for discovering a very specific cellular repair process called autophagy.1
And that strange-sounding little word is the reason that fasting (including modified fasting) is so effective. The word “autophagy” is a combination of the words “auto” (self) and “phagy” (eating). In other words, “autophagy” literally means “self-eating.”
See, your body is a true marvel of design. When calorie consumption cuts off or stays below that magic 800-calorie mark (including during sleep, while you’re sick, or when you’re intentionally fasting), your system starts recycling its own cells — literally destroying and consuming damaged or dying cells to make way for new, healthy cells.
Your body also attacks fat cell accumulations as the least needed, cancerous growths we all have, and viral and bacterial cell clusters that could make us sick. Basically, freed from having to break down food all day, every day — the body goes to work, repairing.
Your miraculous, self-regulating body, in a fasting state, goes into Marie Kondo mode, clearing out that whatever doesn’t serve you.
It’s the reason our need for sleep has as much to do with fasting as it does REM cycles. It’s also the reason we intuitively cut WAY down on calories when we’re feeling really sick.
Frequently Asked Questions About Modified Fasting
If you have a lot of questions right about now, you’re not alone. The internet, the blogosphere, and the publishing world have exploded with information about fasting — intermittent fasting, water fasting, time-restricted eating, and others.
So, what makes modified fasting so great? How is it different from intermittent fasting? What advantages does it have over a longer fast, or a water-only fast? Can you really lose weight (and how much)? How often should you do it? What should you eat and drink? What should you be eating afterward?
I’ve got you covered.
1. What’s the optimal amount of time to fast?
When it comes down to it, the optimal amount of time to fast is the amount of time a person can realistically spend in autophagy, considering both physical and mental factors. (In other words, you’ve still got to do life — and that has to factor into your fasting plans.)
While a week-long, zero-calorie water fast is fantastic for your health, it’s not realistic for most people with a busy work schedule and family life. Based on my research, a three-day modified fast is the right mix of doable and highly impactful for your health. I find that people fall off and feel like a failure when they attempt 5 days of modified fasting —but virtually everyone finishes with 3 days.
2. Is a modified fast better than a water-only fast? What about juice fasts, or dry fasts?
It’s easy to get confused by the sheer number of options for different fasting types. And I’m not here to knock any of them. A water-only fast (zero calorie intake, only water to drink) is wonderful for your health, but very difficult for most people to maintain.
A juice fast has a lot of benefits (and gives you an incredible boost of micronutrients), but autophagy doesn’t kick in nearly as quickly as it does other types of fasting.
And a dry fast (neither water nor food allowed!) can really only be done for one day, max, to avoid some serious health issues related to dehydration.
A modified fast of 3 days feels doable for most people, offers the same health benefits of a water-only fast, and is compatible with real life.
3. How does modified fasting differ from intermittent fasting or time-restricted eating?
Modified fasting is a type of intermittent fasting, and includes some time-restricted eating.
A 12-hour feeding window is basic common sense for good health. This is something we should be practicing all year long, and doesn’t quite qualify as fasting. For autophagy to really kick in, a modified fast of 600-800 calories is needed, in addition to maintaining an “eating window” of 8-12 hours each day during the modified fast.
Throughout history, people have limited their “eating window” from 7 am to 7 pm or even shorter; the modern American phenomenon of eating all day and even into the night is a product of cheap, easily available food.
4. Isn’t five days better than three days of fasting?
Based on my own research, a three-day window of modified fasting is simply more doable for the vast majority of people. And that three-day window is enough time for your body to do some serious work in autophagy, clearing out damaged cells, reducing inflammation, and improving so many markers of good health.
If you want to extend your fast to five or six days, all the better! But I find that many people who set out with a specific goal of five days, instead of three, have high dropout rates. Three days seems to be the magic number for a do-able, realistic fast that doesn’t interfere with your social life.
5. How much weight can you lose with modified fasting?
Our first group of modified fasters (who used my Flash Fast program, which includes three days’ worth of organic, prepared mini-meals), lost an average of 4 pounds in 3 days. Think about what that means over the course of a year:
If you did a (modified) Flash Fast every month, that’s a possible 48-pound weight loss in one year, even changing nothing else in the year-round diet.
6. How do you start a modified fast?
It’s really simple.
- Choose three days in a row.
- Plan your plant-based, nutrient-dense meals to total 650-800 calories per day.
- Eat within a 8-12 hour window each day (or get an easy Flash Fast kit, with all your meals ready to go).
Your satiety level will be best if your plant-based diet is higher in protein than most vegan diets. Our first 100 beta testers of the Flash Fast reported an average highest hunger level of 3.4, on a 1 to 10 scale!
7. What should you eat and drink during a modified fast?
Liquids appropriate for a modified fast include lemon water, organic herbal tea, celery juice, and good old fashioned filtered water.
I recommend including 13 grams of protein, four times per day during the fast, as well as good omega fatty acids from flaxseed or hemp seed. You may wish to include raw greens, plus steamed vegetables or a piece of fruit. Your total intake of calories should not exceed 800 calories daily to stay within what is known, from the published clinical research on how to achieve the benefits of fasting, while still eating.
If you plan your own menu for a modified fast, take special care to include plenty of micronutrients from organic sources.
Or, use the Flash Fast kit, which has all the food you’ll need for three days (and allows for unlimited greens blended into your shakes, or eaten without oils added, and some non-starchy veggies or one serving of fruit is also allowable as additions, keeping you under 800 calories).
8. Should men and women do modified fasting differently?
As of this time, no one has done a study to prove or disprove that men can eat more than women during modified fasting, and still gain all the autophagic and ketotic health benefits. So, to be true to the published studies, I can say only 800 calories or fewer for both genders. If I learn of any new evidence that men can follow different guidelines than that, I will update this blog post.
9. Are alcohol and coffee off-limits during a modified fast? What about decaf?
Don’t compromise your results by drinking caffeine or coffee (even decaf coffee) during your modified fast. Not only is coffee dehydrating, but it’s incredibly acidic and can undermine your results significantly.
You’ll also want to eliminate alcohol from your diet during the fast, since it will tax your liver and make it harder to flush toxins and fat stores.
10. Can I exercise during a modified fast?
Yes! Most people find that while they prefer workouts that are lighter or less intense while fasting, you should feel free to listen to your body and stay as active as you wish. If your body tells you to slow down a little, be willing to respond accordingly — after all, you’re doing a lot of unseen work during your fast!
11. What should I eat after a modified fast?
What you eat after a fast is important. When “refeeding” your body after a fast, you’ll be fueling new cell growth as your body rebuilds the “broken parts” stripped down by the process of autophagy.
You’ll want to eat plenty of organic fruits and vegetables, non-gluten whole grains, legumes, nuts, seeds, and only very small portions of wild-caught, free range, or grass-fed animal products (if you choose to eat any animal products at all). Avoid dairy, processed food, stimulants like caffeine, and artificial flavorings and other chemicals.
10. How often can I do a modified fast without slowing down my metabolism?
Modified fasting can be done up to weekly without fear of lowering your metabolism.4 For those with significant health challenges or who have a lot of weight to lose, you can safely fast once per week (meaning three days out of every seven).
Our ancestors were incredibly familiar with food scarcity, and most humans around the globe, until about 100 years ago, had long periods of time with only one or two meals per day. (In fact, as strange as this may seem to North Americans, many indigenous cultures around the world currently eat one or two meals a day.)
Our bodies know just how to take advantage of those conditions! While modern society offers us food 24-7, making the choice to fast regularly is one of the smartest things you can do for your health.
13. Is there anyone who shouldn’t do a modified fast?
The great thing about a modified fast of three days is that it’s accessible for a lot of people for whom fasting generally isn’t a great option, including older adults.
Water fasting isn’t recommended for pregnant women during the first few months of exclusive breastfeeding or for people who have an eating disorder, hypertension, diabetes, kidney disease, or heart disease.
People in cachexia (muscle wasting) from stage IV cancer should consult their physician, but even modified fasting is usually contra-indicated in this situation.
When in doubt, talk with your trusted functional medicine doctor about whether a modified fast is right for you.
14. Should I be worried about muscle loss during modified fasting?
No! It’s a common myth that the body will start metabolizing muscle as soon as you enter a fasted state. You’d have to fast for quite a long time for that to happen. During a fast, your body will use up your fat stores 4 (that’s a big reason they exist, to get you through a famine!), as well as breaking down damaged bits of protein and cells for fuel (autophagy). During a modified fast, you’ll also be eating enough protein and micronutrients to maintain muscle tissue.
15. Are there any challenges I should prepare for?
Many people experience something called “Herxheimer reactions” during a fast, as toxins that have been tucked away in your fat tissue flood through your organs on their way out of your body. You might experience headaches, digestive issues, or other brief symptoms. Know that this is normal, and actually, it’s a good sign of how much your body needed to detox. Keep drinking water to help flush these toxins out, and consider a coffee enema to help speed up the process.
16. What kind of health benefits should I expect to see from modified fasting?
This is the most important question, and I’ve saved it for last because it deserves its own section, up next! Here’s the short version when it comes to the health benefits of modified fasting:
- allows your body to burn abdominal fat stores for weight loss
- recycles damaged cells
- triggers cellular regeneration
- triggers human growth hormone and stem cell production
- boosts the immune system
- improves memory and cognition
- slows bone loss
- increases life span
- fights tumor growth
- reverses fatty liver syndrome
- decreases overall cholesterol and blood pressure
- decreases overall inflammation
- balances the hormone (endocrine) system
- regenerates the myelin sheath, preventing MS, Alzheimers, Parkinson’s, etc.
- breaks down cancerous growths
- helps reverse metabolic syndrome
. . . and the list goes on!
The Unique Benefits of Modified Fasting
The benefits of modified fasting3 are right on par with the benefits of water fasting. And most importantly, these benefits are accessible and doable for the average, busy person.
Fasting Compatible with Modern Life
I can tell you right now that water fasting isn’t easy. There’s a reason that I (and others) attend fasting clinics, instead of staying at home with easy access to the refrigerator! Modified fasting, on the other hand, requires zero white-knuckling and can be done while traveling, caring for children, at work, and in the middle of real life.
If you feel up to a water-only fast, or a longer modified fast, I’m your biggest cheerleader. But for those of you who think “there’s no way I could fit an extended water fast into my life,” modified fasting is an amazing choice.
Doable, Non-Threatening, and Easy
Going completely without food for any stretch of time isn’t doable for most people. But a very specific, low-calorie fast on the other hand? That’s manageable. Especially given that the research shows that eating an optimized, low-calorie (650-800 calories, to be exact) diet during a short-term fast yields the same benefits of a water-only fast — along with being far more doable.
You won’t even be particularly hungry.
Modified fasting basically lets you have your carrot cake and eat it too. (Or at least your carrot. No cake. Sorry.)
Cell Repair and Waste Management
Even if you’re eating a mostly raw, nutrient-dense diet, your body is still working hard to run damage control on waste buildup and cellular damage that comes from oxidative stress, the chemical load in your environment, and even normal biological processes like digestion.
Fasting cuts down on the enormous amount of energy required for digestion and opens the door for cell repair and waste removal.5 It’s one of the reasons we need sleep so much when we’re sick or stressed out: to give our bodies a chance to manage repairs and waste removal without the burden of actively digesting a full load of calories. During a modified fast, you’ll choose an 8-12 hour eating window (during which you’ll consume all of your 5 daily mini-meals) to allow your body plenty of time to rest from digestion and spend the maximum amount of time in autophagy.
A modified fast can significantly lower inflammation and oxidative stress.6 On an average day of digestion, your mitochondria (the energy-production centers in your cells) process quite a bit of glucose from the food you eat, which inevitably creates byproducts known as free radicals (unstable molecules that cause cell and organ damage), as well as cells called monocytes, which trigger inflammation.7
The average person’s basal metabolic rate is between 1400-1600 calories per day (that’s how many calories you burn during a given day just by being alive). During a modified fast, you’ll be eating significantly fewer calories, significantly less glucose, and producing significantly fewer free radicals and monocytes during digestion.
Many people with inflammatory conditions like arthritis, Crohn’s, irritable bowel syndrome, and psoriasis8 notice improvements during and after a fast for this reason.
Flush Toxins and Chemicals
The average person is exposed to around 80,000 different chemicals in the air, food, and water.9 And you’d better believe that chemical load has an impact. Our bodies are amazingly adept at protecting us from the harmful effects of those chemicals, by tucking them away in fat stores10 where they can’t damage our organs. But in modern society, it’s difficult for our bodies to keep up with the number of chemicals in the plastics, metals, drugs, food, air, and water we interact with on a daily basis. Disease is the direct result of chemical overload, and fasting can be a literal lifesaver in helping our bodies play catch-up with a chemical-saturated environment.
Weight Loss and Reduced Fat Marbling in Organs
Modified fasting is one of the easiest, most effective way to lose weight (especially abdominal fat!) quickly.4 The average person who participated in my Flash Fast program lost 4 pounds in three days.
And no, that’s not just “water weight.” During autophagy, your body goes after fat stores first, for fuel — particularly abdominal fat stores — 3 along with recycling and destroying damaged tissues and cells for fuel. Fasting also helps improve fatty liver syndrome,25 which results in fat marbling you can’t see in your liver and other internal organs. Fatty liver syndrome also puts a big strain on blood circulation, and hurts your liver’s ability to flush toxins and chemicals from your body.
Improved Mood and Brain Health
New research shows that fasting (including modified fasting!) can be as effective as antidepressants11 in improving mood and mental health. Many researchers believe that the process of autophagy in the brain’s neurons is responsible for the findings.
Other studies show that temporary calorie restriction through modified fasting boosts brain-derived neurotrophic factor12 (which in animal studies helps protect neurons in the brain against damage, stress, and dysfunction from neurodegenerative disorders), as well as encouraging the growth of new neurons. Regular fasting in mice produces new nerve growth in the hippocampus (the place we create new memories), as well as improved cognition.
Protects and Restores Nerve Cell Function
Nerve cells rely on a special kind of insulation, called a myelin sheath, to properly communicate with each other. The condition Multiple Sclerosis (MS) develops as these myelin sheaths erode, making it difficult and ultimately impossible for nerves to carry information and communicate with each other.
No drug on the market has been able to successfully restore these myelin sheaths. But as it turns out, fasting can do what drugs can’t: One clinical trial showed that fasting can reverse damage from Multiple Sclerosis 13 to the fatty tissues that protect and insulate nerve cells, and actually help rebuild the myelin sheaths.14
Immune Boost and Protection Against Disease
Fasting provides a significant immune boost, partly because during autophagy, your body is actively scavenging for damaged, mutated, or low-functioning cells, and partly because a fast helps reset important metabolic and neurological pathways. When those pathways are working effectively, your microbiome, enzymes, and hormones can more effectively flush toxins, repair damage, and convert food into energy.
A study in 2019 showed that fasting mice were able to destroy pathogens in about two days,15 while their well-fed counterparts took an entire week ro do the same thing. And a 2014 study showed that fasting causes dormant stem cells involved in immune functions to regenerate.16
Research shows that fasting can help animals recover from bacterial infections17 more quickly. It’s also been shown to improve cardiovascular health, diabetes, neurodegenerative conditions, autoimmune diseases, and even cancer.
It turns out “starve a fever, feed a cold” is an old wives’ tale. Starve a cold, too. The immune system becomes strong and energized to metabolize the viral or bacterial colonies, to help you get well quickly and help you avoid longer-term consequences like pneumonia or deep respiratory congestion.
There are numerous studies show how fasting and intermittent calorie restriction increase lifespan in animals from mice to chimpanzees.18
And while there aren’t any conclusive human studies, scientists are confident that these many animal studies apply to people too.
When you look at all of the different health benefits of fasting (cell repair, waste management, immune health, lowered inflammation, and better mental health), it’s no wonder!
All of us have cancerous cells in our body: mutated, damaged cells that result from toxins, sun damage, or oxidative stress. Regular fasting, and the autophagy that accompanies it, helps aggressively clear those damaged, mutated cells out of our bodies on a regular basis.
Fasting can also help people who’ve received a cancer diagnosis already. A study conducted by USC19 found that a diet with regular fasting weakened cancer cells so that chemo was more effective, and helped healthy cells stay more resistant to damage from chemotherapy.
Improves Markers of Diabetes
Regular fasting has also been proven to improve insulin sensitivity and help decrease your risk of developing metabolic syndrome and diabetes. One study from 2017 showed that pre-diabetic mice were able to begin secreting insulin normally again,20 as well as regenerating pancreatic β cells21 — significant markers in the progression of diabetes.
Protects Against Heart Disease
In one study, 71 participants were asked to complete three cycles of a 5-day fasting-mimicking diet. The results, which showed lower blood pressure, lower total cholesterol, weight loss, and lower C-reactive protein22 (a marker of inflammation associated with heart disease), were significant.
Advantages of a Modified Fast vs. Longer Fasts
While a shorter fast is obviously more doable and compatible with a busy modern life, there are a few other important advantages to consider as well.
Basically, there’s no need to feel like you’re selling yourself short, or “taking the easy way out” by fasting for shorter periods of time on a regular basis, rather than all at once during a strict water-only fast. Here’s why!
No Risk of Muscle Wasting
While your body can easily go for long periods of time without consumed fuel (several weeks, actually), it can’t run on fat stores alone. Your brain relies heavily on glycogen to function.23 During water-only fasts that last up to three days, your body can rely on stores of glycogen in the liver, combined with fat stores. However, longer fasts without any other food force the body to start breaking down muscle tissue/protein for glycogen. Shorter modified fasts of 3-5 days won’t dip into muscle stores for that precious glycogen!
Maintains a Healthy Metabolism
A longer water-only fast can slow down your metabolism, since your body will be working to conserve energy. There’s no long-term harm from this, as long as you don’t do long-term water fasts regularly. However, one of the advantages of a shorter modified fast is that it can be done much more regularly without fear of slowing the metabolism.4
Avoids Complications of Refeeding Syndrome
Longer, water-only fasts can, in rare circumstances, result in a dangerous condition known as refeeding syndrome.24 This syndrome is caused by a sudden influx of calories that leads to a drastic imbalance in electrolytes in the body. In very rare situations, refeeding syndrome can be deadly.
While it is important to re-enter a normal diet after fasting with special care to nutrients and organic foods, there’s no risk of refeeding syndrome after a shorter, modified fast.
Flexibility and Compatibility with Daily Life
I can tell you from personal experience that it’s very difficult to undertake a water-only fast without serious focus (and sometimes isolation). A modified fast allows you to stay social, keep up with work and everyday activities (like making dinner for your family), without calling it quits on your fast or feeling overwhelmed.
Tips for a Successful Modified Fast
While fasting for three days is doable for most people, you’ll have the very best chance of success if you keep the following tips in mind:
While you’re fasting, your body will be working hard to flush toxins and waste from your system more aggressively than usual. That means you’re going to go through electrolytes and liquids more quickly. Stay hydrated, and keep your electrolyte levels high by spreading your mini meals out evenly throughout the day. If you feel light-headed, or have a headache, sip on some lemon water or celery juice, which are low or zero-calorie, but rich in electrolytes.
Listen to Your Body
Listen to your body’s signals during a fast! Rest as needed, plan plenty of time for high-quality sleep, and don’t panic if you notice some of those Herxheimer reactions we talked about earlier. Headaches and tiredness early on in the process are very normal, and they will pass. Your body is doing important work!
Find Your Cheerleaders
A support group can make all the difference to success, as well as helping you find answers to your questions that may arise during a modified fast like the Flash Fast.
We’ve started a free Flash Fast Support group with experienced health coaches,just for this purpose, and we’d love to have you there, on Facebook!
Conclusions About Modified Fasting
There’s no doubt that research showing the benefits of fasting is one of the most important health discoveries of this century.1 In a modern world filled with chemicals, processed food, and 24/7 snacking, fasting gives our bodies a chance to “take out the trash,” as well as renew, rebuild, and recycle damaged cells.
Modified fasting makes the benefits of fasting accessible to almost anyone, in a way that’s compatible with real life. Whether you’re interested in losing weight, clearing out damaged cells and toxins from your body, fighting disease, reducing inflammation, or improving your mental health (and who isn’t interested in ALL of those things?), modified fasting is one of the best things you can do for your health.
Listen Next: Vibe Episodes 146 & 147: How To Get The Remarkable Benefits of Fasting–Without Going Hungry!” With Robyn Openshaw
Robyn Openshaw, MSW, is the bestselling author of The Green Smoothies Diet, 12 Steps to Whole Foods, and 2017’s #1 Amazon Bestseller and USA Today Bestseller, Vibe. Learn more about how to make the journey painless, from the nutrient-scarce Standard American Diet, to a whole-foods diet, in her free video masterclass 12 Steps to Whole Foods.
- Levine B, Klionsky DJ. Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker’s yeast fuel advances in biomedical research. Proc Natl Acad Sci U S A. 2017;114(2):201–205. doi:10.1073/pnas.1619876114
- Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018;10(7):e2947. Published 2018 Jul 9. doi:10.7759/cureus.2947
- Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and clinical applications. Cell metabolism, 19(2), 181–192. doi:10.1016/j.cmet.2013.12.008.
- Fung, Jason Dr. How to Fix Your Broken Metabolism by Doing the Exact Opposite. Intensive Dietary Management.
- Anton SD, Moehl K, Donahoo WT, et al. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring). 2018;26(2):254–268. doi:10.1002/oby.22065
- Martin B, Golden E, Egan JM, Mattson MP, Maudsley S. Reduced energy intake: the secret to a long and healthy life?. IBS J Sci. 2007;2(2):35–39.
- Jordan, Stefan. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. (2019). Cell.
- Berger, Matt. “How Intermittent Fasting Can Help Lower Inflammation.” Heathline. August 22, 2019.
- Fitzgerald, Randall. The Hundred-Year Lie: How to Protect Yourself from the Chemicals That Are Destroying Your Health. Dutton. 2006.
- Jackson E, Shoemaker R, Larian N, Cassis L. Adipose Tissue as a Site of Toxin Accumulation [published correction appears in Compr Physiol. 2018 Jun 18;8(3):1251]. Compr Physiol. 2017;7(4):1085–1135. Published 2017 Sep 12. doi:10.1002/cphy.c160038
- Gassen NC, Rein T. Is There a Role of Autophagy in Depression and Antidepressant Action?. Front Psychiatry. 2019;10:337. Published 2019 May 15. doi:10.3389/fpsyt.2019.00337
- Mattson MP. Energy intake, meal frequency, and health: a neurobiological perspective. Annu Rev Nutr. 2005;25:237–260
- University of Wisconsin-Madison. “Discovery opens new opportunities to slow or reverse multiple sclerosis.” ScienceDaily. ScienceDaily, 27 November 2018.
- Choi, I. Y., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., … Longo, V. D. (2016). A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell reports, 15(10), 2136–2146. doi:10.1016/j.celrep.2016.05.009
- Collins, Nicholas. The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. (2019). Cell.
- Cheng, Chai-Wei. Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression. (2014). Cell Stem Cell.
- Mohapatra, Sipra, et. al. “Short-term starvation and realimentation helps stave off Edwardsiella tarda infection in red sea bream (Pagrus major).” Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. Volume 206, April 2017, pages 42-53.
- Heilbronn L.K., de J.L., Frisard M.I., DeLany J.P., Larson-Meyer D.E., Rood J., Nguyen T., Martin C.K., Volaufova J., Most M.M., et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial. JAMA. 2006;295:1539–1548. doi: 10.1001/jama.295.13.1539.
- Brandhorst S, Longo VD. Fasting and caloric restriction in cancer prevention and treatment. Recent Results Cancer Res. 2016;207:241-266. doi:10.1007/978-3-319-42118-6_12
- Cheng, Chia-Wei et al. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 02/2017.
- Cheng, C. W., Villani, V., Buono, R., Wei, M., Kumar, S., Yilmaz, O. H., … Longo, V. D. (2017). Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell, 168(5), 775–788.e12. doi:10.1016/j.cell.2017.01.040.
- Wei, Min et al. Fasting-Mimicking Diet and Markers/Risk Factors for Aging, Diabetes, Cancer, and Cardiovascular Disease. Science Translational Medicine. 02/2017.
- Mathieu C, Li de la Sierra-Gallay I, Duval R, et al. Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE. J Biol Chem. 2016;291(35):18072–18083. doi:10.1074/jbc.M116.738898
- Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008;336(7659):1495–1498. doi:10.1136/bmj.a301
- Ebrahimi S, Gargari BP, Aliasghari F, Asjodi F, Izadi A. Ramadan fasting improves liver function and total cholesterol in patients with nonalcoholic fatty liver disease. Int J Vitam Nutr Res. 2019 Apr 1:1-8. doi: 10.1024/0300-9831/a000442.
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